Indian Journal of Pharmacy and Pharmacology


To evaluate the effect of pyridostigmine on blood glucose levels in euglycemic albino rats through OGTT


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Author Details: Siddamma Amoghimath, Suresha R N, Shruthi S L

Volume : 4

Issue : 4

Online ISSN : 2393-9087

Print ISSN : 2393-9079

Article First Page : 203

Article End Page : 206


Abstract

Introduction: The effect of Pyridostigmine on blood glucose levels in euglycemic albino rats through OGTT.
Methods: Twelve Swiss albino rats weighing around 150-200gmsof either sex were randomly selected from the central animal facility, and divided into two groups. The control group received distilled water (25ml/kg body wt.), test group received Pyridostigmine (3.6mg/kg/day) for 5 days. All the drugs were given per orally. On the fifth day, following overnight fasting, 1 hour after drug administration OGTT was performed, by administering oral glucose in dose of 0.6gm/kg body weight. The capillary blood glucose level of both the groups were measured at 0, 60 and 150 minutes, by rat tail snipping method using (ACCUCHEK) glucometer.

Results: The Capillary Blood Glucose levels of Pyridostigmine group was less when compared to control group at all-time intervals and was statistically significant when compared to control at all the time intervals.

Conclusion: Pyridostigmine showed the hypoglycemic activity when given for 5 days orally in euglycemic albino rats through OGTT.

Keywords: Oral Glucose Tolerance Test (OGTT), Capillary blood glucose, Diabetes, Pyridostigmine, Euglycemic