Indian Journal of Pharmacy and Pharmacology

To evaluate the effect of pyridostigmine on blood glucose levels in euglycemic albino rats through OGTT

Full Text PDF Share on Facebook Share on Twitter

Author Details: Siddamma Amoghimath, Suresha R N, Shruthi S L

Volume : 4

Issue : 4

Online ISSN : 2393-9087

Print ISSN : 2393-9079

Article First Page : 203

Article End Page : 206


Introduction: The effect of Pyridostigmine on blood glucose levels in euglycemic albino rats through OGTT.
Methods: Twelve Swiss albino rats weighing around 150-200gmsof either sex were randomly selected from the central animal facility, and divided into two groups. The control group received distilled water (25ml/kg body wt.), test group received Pyridostigmine (3.6mg/kg/day) for 5 days. All the drugs were given per orally. On the fifth day, following overnight fasting, 1 hour after drug administration OGTT was performed, by administering oral glucose in dose of 0.6gm/kg body weight. The capillary blood glucose level of both the groups were measured at 0, 60 and 150 minutes, by rat tail snipping method using (ACCUCHEK) glucometer.

Results: The Capillary Blood Glucose levels of Pyridostigmine group was less when compared to control group at all-time intervals and was statistically significant when compared to control at all the time intervals.

Conclusion: Pyridostigmine showed the hypoglycemic activity when given for 5 days orally in euglycemic albino rats through OGTT.

Keywords: Oral Glucose Tolerance Test (OGTT), Capillary blood glucose, Diabetes, Pyridostigmine, Euglycemic