GENETIC ANALYSIS OF PATIENTS WITH PRIMARY OPEN ANGLE GLAUCOMA (POAG) IN NORTH INDIAN POPULATION
Aim: To investigate the role of the methylenetetrahydrofolate reductase (MTHFR) 677C>T polymorphism in a large cohort of patients with POAG.
Methods: genetic analysis of 80 patients of POAG and 80 controls was done for MTHFR 677C>T polymorphism using PCR.
Results: The C677T genotype is found to be very significantly associated with POAG) as compared to the controls. There is a significant difference in the frequency of distribution of genotype. The homozygous mutant genotype (TT) is also 1.25% more in cases as compared to controls.
Conclusion: There is significant association of MTHFR 677C>T polymorphism with POAG.
Key words: Glaucoma, Intraocular pressure, Primary open angle glaucoma