Contact No: +91-8826373757 | +91-8826859373 | 011-25052216
Email: rakesh.its@gmail.com | editor@innovativepublication.com

The Journal of Community Health Management


GENETIC ANALYSIS OF PATIENTS WITH PRIMARY OPEN ANGLE GLAUCOMA (POAG) IN NORTH INDIAN POPULATION


Full Text PDF Share on Facebook Share on Twitter


Author Details: Abhishek Dixit, Diksha Prakash, Samir Kumar, Mousumi Mutsuddi, OPS Maurya, S P Singh, Abhishek Chand

Volume : 2

Issue : 4

Online ISSN : 2394-2738

Print ISSN : 2394-272X

Article First Page : 168

Article End Page : 178


Abstract

Aim: To investigate the role of the methylenetetrahydrofolate reductase (MTHFR) 677C>T polymorphism in a large cohort of patients with POAG.
Methods: genetic analysis of 80 patients of POAG and 80 controls was done for MTHFR 677C>T polymorphism using PCR.
Results: The C677T genotype is found to be very significantly associated with POAG) as compared to the controls. There is a significant difference in the frequency of distribution of genotype. The homozygous mutant genotype (TT) is also 1.25% more in cases as compared to controls.
Conclusion: There is significant association of MTHFR 677C>T polymorphism with POAG.

Key words:
Glaucoma, Intraocular pressure, Primary open angle glaucoma