The Journal of Community Health Management

Study of Prevalence of Drug Resistant Tuberculosis in a Tertiary Care Hospital

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Author Details: DK Shah, JK Mishra

Volume : 3

Issue : 1

Online ISSN : 2394-2738

Print ISSN : 2394-272X

Article First Page : 19

Article End Page : 22


Pulmonary tuberculosis with multi-drug resistant Mycobacterium tuberculosis is a major cause of concern in the developing countries. The present study was carried out to study the prevalence of multi-drug resistant tuberculosis (MDR-TB) in clinical isolates at Sir Sunderlal hospital in Banaras Hindu University, Varanasi, India, which is a tertiary care hospital. One hundred and eighty nine (189) sputum samples were collected from clinically suspected cases of tuberculosis and subjected to Zeihl-Neelsen stains (ZN) and culture on Lowenstein-Jensen (LJ) medium and 46 cultural isolates were obtained and subjected to drug susceptibility against Isoniazid (INH) and Rifampicin (RIF). A total of nine (19.5%) isolates were found to be resistant against INH and two strains (4.5%) was found to be resistant against both RIF and INH. No strain was found to be resistant against Rifampicin alone. The present study revealed the presence of 4-6% of multi-drug resistant M. tuberculosis infection in patients attending Sir Sunderlal hospital in Banaras Hindu University. This emphasizes the need for strengthening laboratory services for timely diagnosis of MDR TB.

Pulmonary tuberculosis, drug susceptibility, Isoniazid, Rifampicin