Volume : 4
Issue : 1
Online ISSN : 2394-2738
Print ISSN : 2394-272X
Article First Page : 30
Article End Page : 34
Background: Polycystic ovarian syndrome (PCOS) is the metabolic endocrine disorder that affects 4–12% women of reproductive age and is a major cause of anovulatory infertility. Besides reproductive and obstetric complications, the consequences of PCOS extend beyond the reproductive axis and may lead to the substantial risk for the development of metabolic syndrome with the characteristic features of insulin resistance, central obesity, impaired glucose tolerance, dyslipidemia and hypertension.
Objectives: To evaluate the hormonal status and its association with the anthropometric measurements and biochemical parameters in females diagnosed with PCOS.
Materials & Methods: In this case-control study, women clinically diagnosed with PCOS (N=85) and age matched healthy control female subjects (N=85) in the age group (18 – 35) years were enrolled. Body mass index (BMI), waist: hip ratio (WHR), Fasting Blood Glucose, Lipid profile and Hormonal levels were estimated in both the groups and further compared using student t-test. Hormonal levels were also correlated with the anthropometric measurements & biochemical parameters and the results were analyzed using Pearson’s correlation coefficients.
Results: We found that the levels of TSH, LH, FSH, LH/FSH ratio & prolactin were significantly raised in PCOS females as compared to healthy females (P < 0.0001). TSH showed significant positive correlation with anthropometric measurements (BMI, waist-to-hip ratio), biochemical parameters (TC, TG, LDL & TC/HDL ratio) and hormonal profile (LH, FSH, LH/FSH ratio & Prolactin) of PCOS women.
Discussion & Conclusion: We found that there is a derangement in hormonal & biochemical status of women suffering from PCOS that leads to an altered energy metabolism and endocrinological cascade of PCOS. Furthermore, our study showed high prevalence of hypothyroidism, dyslipidemia and increased levels of LH, FSH, PRL & a higher LH/FSH ratio in women with PCOS, which may further contribute towards the progress of metabolic disorders, irregular menstruation and infertility.
Keywords: Polycystic Ovarian Syndrome, Thyroid Stimulating Hormone, Body Mass Index, Hypothyroidism, Dyslipidemia, coronary artery disease