Distribution of lymphoid neoplasm in eastern India: An experience from a tertiary care cancer research institute
Introduction: The classification of lymphoid neoplasm has witnessed significant revisions over the years with the recent one simplifying the diagnosis and management of lesions at the very initial stages of lymphomagenesis. Different subtypes of lymphoid neoplasm vary in the different geographical locations. The present study aimed to probe the distribution of lymphoid neoplasm in Eastern India.
Materials and Methods: A total of 79 cases of lymphadenopathy were included over a period of two years and were subjected to categorization according to WHO classification, using light microscopy and immunohistochemistry studies.
Results: Of the 79 cases of lymphadenopathy studied, 35 cases were NHL, 21 cases were HL and rest other types. The ratio of NHL to HL as per our study was 1.66:1. Among NHL cases B-cell lymphomas were the predominant type accounting for 77.78% of all NHL cases, while T-cell lymphomas constitute 17.78% cases. Among HL, mixed cellularity variant was the commonest type (52.38%). followed by nodular sclerosis (33.33%) and lymphocyte predominance (9.52%).
Conclusion: While DLBCL was the most common prevalent B cell NHL subtype followed by follicular lymphoma, Burkitt's lymphoma and High Grade B Cell lymphoma, ALCL was the most common T-cell lymphoma subtype followed by peripheral T cell lymphoma and Mycosis fungoides. Mixed cellularity was found the most common subtype of HL followed by the nodular sclerosis.
Keywords: Hodgkin’s lymphoma, Lymphoid neoplasm, Non-Hodgkin’s lymphoma.