Volume : 4
Issue : 1
Online ISSN : 2393-9834
Print ISSN : 2320-7302
Article First Page : 21
Article End Page : 25
Introduction: The aim of the study was to evaluate the sustained release effect of 2% chlorhexidine and its combination with 2% chitosan, in vitro.
Method: The sustained release effect of chlorhexidine and its combination with chitosan was determined using a UV spectrophotometer.
Results: UV spectrophotometer analysis for the sustained release of chlorhexidine showed that almost 100% of chlorhexidine was released within 4 hours. However when chlorhexidine was combined with chitosan, only 59% of chlorhexidine release was observed even at 24 hours.
Conclusion: The percentage drug release of chlorhexidine was almost half when used in combination with chitosan, thus indicating the sustained release property of chitosan.
Key words: Chitosan, Chlorhexidine, Sustained Release Effect