Journal of Oral Medicine, Oral Surgery, Oral Pathology and Oral Radiology

Synchronous squamous cell carcinoma of the lips: A literature review & case report

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Author Details: Riaz Abdulla, Durbakula Karteek, M. Muhaseena, Mandeep Kaur

Volume : 3

Issue : 1

Online ISSN : 2395-6194

Print ISSN : 2395-6186

Article First Page : 51

Article End Page : 55


Oral cancer is the sixth most common cancer worldwide accounting for 2–4% of all cancer cases. Second primary tumors (SPT), are considered to be a poor prognostic indicator for overall survival. Synchronous tumors are the SPTs that occur simultaneously or within 6 months of the index tumor. Synchronous squamous cell carcinoma frequently occurs in oral cavity (39%) with incidence rates of the lip ranging from 10 – 18%. SPTs are usually aggressive in nature with early metastasis and therefore require more aggressive treatment. We report a rare case of synchronous oral squamous cell carcinoma occurred in a relatively young patient (< 40 years) involving both upper and lower lips with literature review focusing on the pathogenesis and various studies that reported synchronous Oral Squamous Cell Carcinomas of the lip.

Squamous cell carcinoma; Second primary tumor; Synchronous tumor; Field cancerization; Patch theory; Vertical recruitment