Journal of Oral Medicine, Oral Surgery, Oral Pathology and Oral Radiology


Mammary analogue secretory carcinoma - A case report


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Author Details: Nandhini.V

Volume : 3

Issue : 4

Online ISSN : 2395-6194

Print ISSN : 2395-6186

Article First Page : 234

Article End Page : 237


Abstract

Introduction: Mammary analogue secretory carcinoma (MASC) is a recently described salivary gland tumor that harbors the recurrent ETV6-NTRK3 translocation.(1) With this paper we report a rare case of MASC of the parotid salivary gland due to its rarity and a review of this disorder.
Case Report: A62yr old Male presented with a recurrent solitary swelling in his left parotid region. A CT of head & neck revealed a 5x4 cm well circumscribed radio opacity in the left parotid gland. The patient presented with no symptoms and had no co morbidities. A sample of the lesion was obtained for histopathological study, which yielded a definitive diagnosis of oncocytoma .He was operated for the same with wide surgical excision and reconstruction with PMMC flap and close monitoring and regular follow up care was done.
Discussion: According to the 2005 WHO Classification of Head and Neck Tumors, the groups of malignant epithelial salivary gland tumors contain many heterogeneous entities. The histomorphological classification of these tumors is complex, and their clinical behavior is not completely elucidated, partly because they are rare. Some entities, such as adenocarcinoma/cystadenocarcinoma NOS, might encompass subtypes still to be discovered by molecular analysis. Careful histomorphological examination of cases that did not entirely fulfill the criteria of one given entity in conjunction with a typical pattern of expression of immunohistochemically markers enabled Skalova et al to define mammary secretory analogue carcinoma (MASC) as a new entity.

Keywords: Mammary analogue secretory carcinoma, MASC, Salivary gland, ETV6-NTRK3 fusion, Translocation t (12;15)