Journal of Pharmaceutical and Biological Sciences


Physiological mechanisms involved in longer life span!


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Author Details: Kartheek R. Balapala, Madhu Thota

Volume : 5

Issue : 1

Online ISSN : 2320-1924

Print ISSN :

Article First Page : 21

Article End Page : 26


Abstract

Past research indicated association between social relations and longevity among humans. Decline in mitochondrial function with alterations in the nuclear chromatin are seen in old age. Ageing in animals is associated with multiple organ dysfunction, while age related degeneration formed the major factor in human ageing. Low levels of circulating methionine were noticed in naked mole-rats that lived longer, suggesting they had a natural life-extending phenotype akin to that observed among the methionine-restricted animals. Health improving interventions contributed to a better life span. Different rates of ageing are seen among humans of different families and those with exceptional survival give prospective to comprehend why some people age at a slow rate than others. Objective of this review is to identify the key factors that promote longevity.

Keywords: Longevity; Molecular genetics, Nutrition; Reactive oxygen species