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Journal of Pharmaceutical and Biological Sciences


Nanodelivery of herbal drug (via) biocompatabile polymer on MCF-7 cell line


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Author Details: V. Sandhiya

Volume : 5

Issue : 1

Online ISSN : 2320-1924

Print ISSN :

Article First Page : 31

Article End Page : 36


Abstract

The development of new delivery systems for the controlled release of drugs is one of the most innovative fields of research in pharmaceutical sciences. The objective of this work is to prepare and characterize chitosan loaded gallic acid nanoparticales. The organoleptic propertity of the drug were complys with USP standard. The solubility studies were performed. The FTIR studies were carried out for drug with polymer in different ratio which shows there was no chemical interaction between the drug and polymer. The drug content and entrapment efficiency of the nanoparticale was increase as the concentration of polymer increase. The F4 formulation shows more entrapment efficacy compared to other formulations nearly 70.87% and the drug content was found to be 86.7%. The particle size and the surface morphology results revealed that Gallic acid nanoparticles (GNPs) were smoothed spheroidal with a size ranging from 67.2 nm-100.5nm. The in-vitro dissolution studies were carried out for all the Formulation. Formulation F4 shows 97.67% of drug release at the end of 24 hr. The results suggest that chitosan polymer based nanoparticulate formulations are potential means to achieve release of Gallic acid for the prolonged period of time for effective therapy. The results showed that this method is reproducible easily.

Keywords: Gallic acid, nanoparticle, chitosan, ionization-gelation method, MCF-7 cell line