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Journal of Pharmaceutical and Biological Sciences


Toxicological evaluation of the aqueous extract of Pseudocedrela kotschyi (Meliaceae) stem bark in albino rats


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Author Details: Moïse Legentil NCHOUWET, Sylvie Léa WANSI, Mahamat OUMAR, David MIAFFO, Pepin Alango NKENG-EFOUET,

Volume : 5

Issue : 4

Online ISSN : 2320-1924

Print ISSN :

Article First Page : 168

Article End Page : 174


Abstract

Pseudocedrela kotschyi is a monoiceous plant used traditionally to treat many diseases. The present work has been designed to evaluate the toxicological profile of aqueous extract of Pseudocedrela kotschyi stem bark in experimental rats. Acute toxicity was conducted as Organisation for Economic Cooperation and Development guidelines 425 where limit dose of 2000 mg/kg of body weight was used. Body weight, water intake and food consumption were recorded during 14 days. In sub-chronic toxicity test, distilled water or aqueous extract at the doses of 100, 200, 400 mg/kg were daily administrated to rats for 28 days. Haematological, biochemical and histological parameters were evaluated at the end of the treatment. In acute toxicity study, Pseudocedrela kotschyi significantly increased (p˂0.05) food consumption, water intake and relative body weight. In subchronic toxicity study, Pseudocedrela kotschyi significantly increased (p˂0.05; p˂0.001) water intake, food consumption, relative body weight, total protein and HDL-c, and significantly decreased(p˂0.05) LDL-c and triglycerides. Extract significantly increased (p˂0.05; p˂0.001) platelet at doses of 200 and 400 mg/kg. Histopathological examinations showed abnormal architecture of liver and kidney at dose of 400 mg/kg. These findings, therefore supported the traditional believes on effect of the stem barks of Pseudocedrela kotschyi at lower dose.

Keywords:
Pseudocedrela kotschyi, Toxicity, Rats