Journal of Pharmaceutical and Biological Sciences


Modulations in haematological aspects of wistar rats exposed to sublethal doses of fipronil under subchronic duration


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Author Details: Kartheek RM, David M

Volume : 5

Issue : 5

Online ISSN : 2320-1924

Print ISSN :

Article First Page : 194

Article End Page : 198


Abstract

Fipronil (FPN) a phenylpyrazole insecticide is one of the preferred agricultural chemical known for controlling insect pests. Assessment of its safe and toxic levels has become a matter of serious concern as it is occupationally exposed to the farming community. The current investigation was thus aimed to elucidate the changes in haematological indices of Wistar rats on exposure to FPN. Healthy and mature male Wistar rats were randomly assigned into four groups C, E1, E2 and E3 and received 0.0, 6.46, 12.12 and 32.33mg/kg body weight of FPN respectively for a duration of 90 days. The results obtained indicated significant (*p<0.05) changes in RBC, WBC, Hb, PCV, MCH and MCHC values unlike MCV as compared to control. The decline noticed in RBC suggested anaemic conditions of rats. Significant (*p<0.05) elevation in WBC at E1 and subsequent decline at E2 and E3 was also witnessed under current study. As the modulatory outcome of FPN is evident on haematological aspects, it is thereby suggested that FPN under selected doses should be avoided for application into agricultural fields unless precautionary measures are taken to avoid exposure of toxicant as it threatens the health of the mammalian class resulting in compromised haematological condition.

Keywords:
Fipronil, Haematotoxicity, Immune system, Red Blood Corpuscles and Wistar rats