Effectiveness of cardiac markers to detect the increased cardiovascular risk in chronic kidney disease patients
The manifestation of cardiovascular diseases in healthy individuals & patients of CKD differ, the latter owing more than 50% of the mortality to cardiovascular disease, should be diagnosed early of their cardiovascular condition, which is highly conducive in early treatment and reduction in mortality. The standardized tests don’t apply to patients of CKD. The independent way of diagnosis is the elevation of the cardiac enzymes. In the present study, 30 CKD patients and 30 healthy controls were included to find status and cutoff values of the cardiac markers. Findings indicate significant rise in CK-MB and LDH to be an early marker to diagnose CVD in CKD patients. There was no significant rise in the TnI and AST levels, these markers seem to be unavailing in early diagnosis of CVD in CKD patients. No correlation was found between any of the cardiac markers. Considering the difference in the homeostasis and functioning of various organ systems in the control and CKD patients, these cutoff values of general population won’t be conforming to the latter’s condition resulting in under-diagnosis. Therefore, the cutoff values were formulated and calculated to be >13.51 and >286.49 for CKMB and LDH respectively using ROC curve analysis.
Keywords: Chronic kidney disease, cardiovascular disease, Cardiac markers, Troponin I, CK-MB.