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Journal of Pharmaceutical and Biological Sciences


An efficient synthesis of new benzohydrazide and 1, 3-thiazine fused s-triazines as potential antimicrobial agents


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Author Details: G. M. Malik, T. V. Patel

Volume : 6

Issue : 1

Online ISSN : 2320-1924

Print ISSN :

Article First Page : 24

Article End Page : 29


Abstract

As a part of our endeavor toward the synthesis of new heterocyclic bioactive agents, some new substituted 1,3,5 triazine derivatives with 4-nitrobenzohydrazide and 6-(4-methoxyphenyl)-4-phenyl-6H-1,3-thiazin-2-amine and substituted thiourea were reacted and evaluated for their in vitro antimicrobial activity against Gram positive and Gram negative strains using a micro dilution procedure. Synthesized compounds T1GE to T15GE showed to be effective with MIC (µg/mL), among them T5GE, T8GE, T9GE and T14GE showed excellent activity against a panel of microorganisms. The newly synthesized compounds were characterized using IR, 1H-NMR, 13C-NMR, MASS Analysis.

Keywords: Cyanuric Chloride, 4-nitrobenzohydrazide, 6-(4-methoxyphenyl)-4-phenyl-6H-1, 3-thiazin-2-amine, Different thiourea derivatives and antimicrobial activity.

Doi :-https://doi.org/10.18231/2320-1924.2018.0006