MEASUREMENT OF INTRACAMERAL CONCENTRATION OF MOXIFLOXACIN ACHIEVED AFTER TOPICAL APPLICATION OF THE DRUG
Aim: To estimate Intracameral concentration of Moxifloxacin applied topically in different schedule.
Methods: Measurement of moxifloxacin was done in Aqueous aspirated before cataract extraction of different patients instilling topical drug in different schedule.
Results: Significant difference was found between drug concentration of two groups, one instilling single drop of drug 30 min before surgery( 1.20 ± 0.43 µg/ml) and other, instilling 4 drops a day before and one drop on day of surgery (1.80 ± 0.34 µg/ml).
Conclusion: Instilling moxifloxacin drops 1 day before cataract surgery results in higher concentration and is effective in endophthalmitis prevention.
Key Words: Intracameral , Endophthalmitis, Neutrophils